Poster 37

Feb 19, 2017 by AAPOS editor in  Poster Session 2

 Normal Ciliary Body Growth Using Anterior Segment Ultrasound Biomicroscopy 

Kim H. Le; Gianna Stoleru; Mohamad S. Jaafar; Camilo Martinez; Osamah J. Saeedi; Bethany Karwoski; William P. Madigan; Janet L. Alexander

Children’s National Health System, Department of Ophthalmology
Washington DC
University of Maryland, Department of Ophthalmology
Baltimore, MD

Introduction:  The ciliary body (CB) may be important in the pathogenesis of pediatric glaucoma and ultrasound biomicroscopy (UBM) is the best tool for visualizing this anatomy effectively, in vivo. Our understanding of specific UBM structural findings related to the normal pediatric CB is extremely limited. This study aims to use UBM technology to define a descriptive study of CB structural changes with eye growth in normal infants and young adults.

Methods:  UBM of 14 normal eyes from 8 infants and 6 young adults were included in this study.  UBM of the anterior segment focusing on the CB were performed.  Image analysis and data collection were completed utilizing ImageJ software.

Results:  The significant differences in CB measurements between infants and young adults were found in each of the parameters: CB thickness, CB area, CB internal density, trabecular ciliary process distance, angle from CB to corneal endothelium, and angle from CB to iris processes.  These measured parameters confirm an established trend of exponential growth up until age 1, slowed growth from ages 1 to 5, and very minimal growth from ages 5 to 25 years.

Discussion:  All angle structures showed an accelerated growth phase before age 1 and a slow phase up until age 5, mirroring the axial growth of the eye.

Conclusion:  The study established a consistent ocular growth trend for normal pediatric CB measurements using UBM.  A detailed and comprehensive description of normal pediatric anterior segment anatomy and growth is integral to our future studies to better understand CB changes in congenital and childhood glaucoma.

References:  Silverman, RH (2009). High-resolution ultrasound imaging of the eye – a review. Clinical & Experimental Ophthalmology, 37(1), 54-67.

Pavlin CJ, Harasiewicz K, Foster FS. Ultrasound biomicroscopy of anterior segment structures in normal and glaucomatous eyes. Am J Ophthalmol. 1992; 113: 381-9.

Hussein TR, Shalaby SM, Elbakary MA, Elseht RM, GAD RE. Ultrasound biomicroscopy as a diagnostic tool in infants with primary congenital glaucoma. J AAPOS 2007; 11: 546-550

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