The Association Between the Serum Magnesium Level and the Development and Severity of Retinopathy of Prematurity
Sarah Mistrot; Mohammed Hussein
Texas Children’s Hospital, Baylor College of Medicine
Introduction: We evaluated the association between the serum magnesium level, as a surrogate of the autonomic nervous system activity, with the development and severity of retinopathy of prematurity (ROP).
Methods: The serum magnesium level was analyzed in 2 groups of high risk premature infants while in the NICU. The first group had severe ROP requiring treatment. The second group, the control, was comprised of preterm infants who did not develop significant ROP and who were matched for gestational age, birth weight, frequency of intraventricular hemorrhage (p= 1.000), development of septicemia (p= 1.00) and respiratory distress syndrome (p= 0.767).
Results: We included 26 infants in the treatment group and 18 infants in the control. The mean gestational age for the treatment group was 24.85 weeks ±1.71 and 25.28 weeks ±1.31 for the control (p= 0.374). The mean birth weight for the treatment group was 0.677 kg ±0.20 and 0.71 kg ±0.11 for the control (p= 0.575). The mean magnesium level was 2.585 ±0.540 in the treatment group and 2.171 ±0.590 for the control group (p= 0.03). The magnesium level tended to drop significantly over time in the treatment group when compared to the control group (p= 0.050).
Discussion: The serum magnesium level was higher in the treatment group, but tended to drop significantly when compared to the control group.
Conclusion: The serum magnesium level may play an important role in the development and severity of retinopathy of prematurity.
References: Hussein MA, Coats DK, Khan H, Paysse EA, Steinkuller PG, Kong L, O’Brian SE. ‘Evaluating the association of autonomic drug use to the development and severity of retinopathy of prematurity.’ Journal of AAPOS, 2014; 18(4): 332-337
Caddell JL. ‘Hypothesis: the possible role of magnesium and copper deficiency in retinopathy of prematurity.’ Magnes Res, 1995; 8(3): 261-70.